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Office Depot Tip: Is your home office dedicated to being a home office, or is it part of a guest room or the family room? If you don't have to worry about being kicked out of your home office, then portability is not an issue.
If on the other hand, each time your relatives visit, your office (and home) turns into a bed and breakfast, you'll need to put your equipment and files out of the reach and sight. Various furniture manufacturers make cabinets with doors that close to conceal a writing surface, computer equipment and files.
If you work with particulary sensitive materials or documents, consider investing in safe, which come in different sizes and fire resistant models.