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If your leather briefcase is in relatively good condition, cleaning it can be a good alternative to replacing it. Fresh leather briefcase stains from things such as blood and food can be cleaned up quickly with a damp cloth. Stains from oil or grease can be lifted by grinding ordinary blackboard chalk, sprinkling the area, and leaving the powder on for a twenty four hour period. Use a leather care brush to remove the powder and avoid rubbing the powder into the briefcase.
If you expect that your leather briefcase will be subjected to more than typical wear and tear you can consider having your leather pre-treated for extra protection and stain resistance.